ABSTRACT
Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling (FL) in traditional Chinese medicine (TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi (FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu (ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism (glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na-K-ATPase), endocrine system (triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system (acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices (substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome (appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.
Subject(s)
Animals , Humans , Male , Rats , Cold Temperature , Drugs, Chinese Herbal , Energy Metabolism , Poria , Chemistry , Rats, Sprague-Dawley , Treatment Outcome , Yang Deficiency , Drug Therapy , Metabolism , Yin Deficiency , Drug Therapy , MetabolismABSTRACT
Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling (FL) in traditional Chinese medicine (TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi (FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu (ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism (glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na-K-ATPase), endocrine system (triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system (acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices (substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome (appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.
Subject(s)
Animals , Humans , Male , Rats , Cold Temperature , Drugs, Chinese Herbal , Energy Metabolism , Poria , Chemistry , Rats, Sprague-Dawley , Treatment Outcome , Yang Deficiency , Drug Therapy , Metabolism , Yin Deficiency , Drug Therapy , MetabolismABSTRACT
This study was aimed to explore and summarize traditional Chinese medicine (TCM) syndrome differentiation of chronic bronchial asthma,in combination with characteristics of clinical TCM syndrome,clinical phenotype of asthma and the research of genomics in order to provide references.This study was conducted by the method of combining retrospective literature research and clinical epidemiological survey,designing and inducing the formation of chronic duration of bronchial asthma in TCM syndrome observation table,through literature research and analysis and pre-survey feedback information revision method.The four diagnostic data of 204 cases was collected and filled in the observation table.With the help of SPSS22 statistical analysis software,the database was established and the method of cluster analysis was applied to induce the basic TCM syndrome types of chronic bronchial asthma.The results showed that bronchial asthma chronic persistent period was divided into two basic syndromes,which were the cold-deficiency syndrome and heat-deficiency syndrome.It was concluded that the clinical phenotype of bronchial asthma chronic duration was explored for further research on the relationship between TCM syndrome differentiation of cold and heat as well as the modem medicine genomics to provide research data.